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Xiaoyuan (Linda) Zhang






598 Salk Hall
3501 Terrace Street
Pittsburgh, PA 15261


Research Specialist

Research Interests

Phosphophoryn (PP) is a secretory protein and contains a sequence rich in (DSS)n repeat units. This highly acidic and unique sequence of PP possesses all the characteristic features to bind calcium, to initiate the process of mineralization. Ms. Zhang’s research interest is to study the role of PP in the biomineralization process to understand the role of posttranslational modifications on the structure and function of PP, and assess the effect of PP on the mineral formation in different cell lines. Her studies also include PP-induced signal transduction, such as MAPK, and Smad-related signaling pathways, in hMSC, NIH3T3 cell lines.


Jadlowiec JA, X Zhang, J Li, PG Campbell, C Sfeir. Extracellular matrix-mediated signaling by dentin phosphophoryn involves activation of the Smad pathway independent of bone morphogenetic protein. J. Biol. Chem. 2006; 281: 5341-7.

Jadlowiec J, H Koch, X Zhang, PG Campbell, M Seyedain, C Sfeir Phosphophoryn regulates the gene expression and differentiation of NIH3T3, MC3T3-E1, and human mesenchymal stem cells via the integrin/MAPK signaling pathway. J. Biol. Chem. 2004; 279: 53323-30.


Jadlowiec JA, Koch H, X. Zhang, et al. phosphophoryn regulates osteoblast differentiation via integrin signaling and MAP kinase pathway J. Bone. Mineral Res 2004; 19:S273-S273.

Charles Sfeir, J. Li, X. Zhang, Dong H Lee, Hsu-Feng Ko, Dana Olton and Prashant Kumta Biomineralization analysis in nimeralizing and non mineralizing mammalian cells.  IADR Baltimore March 2005.

J.A. Jadlowiec, X. Zhang, J. Li. P.G. Campbell, and C.Sfeir. Phosphophoryn activates the Smad signaling pathway. IADR-Baltimore, March 2005.

Jadlowiec,J.A., X. Zhang, J Li, P Campbell, and C Sfeir. Phosphophoryn Signaling Mechanisms, IADR-Pittsburgh March 2005.

Sfeir,C., J. Li, X. Zhang, D.-H Lee, H.-F.Ko, D. Olton, ,and P. Kumta, Biomineralization in Mineralizing and Non-Mineralizing Cells, IADRPittsburgh, March 2005.

Jadlowiec,J., X. Zhang, N.Piesco, P.Campbell, Sfeir,C. MAPK and Smad 1 Activation by Phosphophoryn ,IADR-Pittsburgh, Dec, 2005.

Julie Jadlowie , Jinhua Li, Xiaoyuan Zhang, Nicholas Piesco. Phil Campbell and Charles Sfeir “Phosphophoryn signaling network” Gordon Research Conference (Smad1 integrin-Binding Proteins)-Big sky, MT Sep. 2005.

Xiaoyuang Zhang, Jinhua Li, Julie Jadlowiec, Phil Campbell, Dana Olton, Hsu-Feng Ko, Dong-Hyun Lee. And Prashant Kumta. “Nanostructure Bioceramic, Polymer-Ceramic Composite Gels and the Role of Extra cellular matrix Proteins of Mineralized Tissues in Signaling and Biomineralization”. Gordon Research Conference (Biomaterials-Biocompatibility/Tissue Engineering)-Plymouth, NH Jul. 2005.

 Julie Jadlowiec, Jinhua Li, Xiaoyuan Zhang, Nicholas Piesco, Phil Campbell and Charles Sfeir “MAPK and Smad 1 Activation by Phosphophoryn”. IADR-Orlando, FL March 2006.






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